Cancer Biology & Medicine | 中性粒细胞在肿瘤微环境中的复杂作用：新型免疫疗法的途径

【Cancer Biology & Medicine】Complex role of neutrophils in the tumor microenvironment: an avenue for novel immunotherapies

复旦大学

DOI: https://doi.org/10.20892/j.issn.2095-3941.2024.0192

该封面图由格索普生物制图团队创作

Abstract

Neutrophils play a key role in the tumor microenvironment, contributing significantly to anti-tumor immunity. They destroy cancer cells using mechanisms such as releasing reactive oxygen species (ROS), forming neutrophil extracellular traps (NETs), and facilitating antibody-dependent cytotoxicity. In addition to their direct tumor-killing abilities, neutrophils can present tumor antigens to T cells, kickstarting adaptive immune responses, particularly when dendritic cells are less active. Moreover, they interact with T cells, natural killer (NK) cells, and B cells, enhancing the overall immune defense. Acting as a crucial link between innate and adaptive immunity, neutrophils represent a promising avenue for advancing cancer immunotherapies. Understanding their varied roles could pave the way for innovative, targeted treatments. 

摘要

中性粒细胞在肿瘤微环境中起着关键作用，对抗肿瘤免疫有重大贡献。它们通过释放活性氧（ROS）、形成中性粒细胞外陷阱（NETs）和促进抗体依赖性细胞毒性等机制破坏癌症细胞。除了直接杀死肿瘤的能力外，中性粒细胞还可以向T细胞呈递肿瘤抗原，启动适应性免疫反应，特别是在树突状细胞活性较低的情况下。此外，它们与T细胞、自然杀伤（NK）细胞和B细胞相互作用，增强整体免疫防御。中性粒细胞作为先天免疫和适应性免疫之间的关键联系，是推进癌症免疫治疗的一条有前途的途径。了解它们的不同作用可以为创新、有针对性的治疗铺平道路。

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